Saw Palmetto is an herbal extract taken from the fruit Of those Dwarf tree discovered largely in Florida in the USA.
What is Saw Palmetto Employed for in Medicine?
It’s most prominent use by far has been for the reduced Urinary tract symptoms related to Benign Prostatic Hypertrophy (BPH). But
this herbal remedy hasn’t yet been welcomed with open arms by mainstream Western medicine, that choose instead to focus on
surgical and pharmaceutical treatments for treatment of an enlarged prostate.
A Current systemic inspection Estimated the incidence of symptomatic BPH increases from 14.8percent in males aged 40 to
36.8percent in males aged 80 and above
The reasons causing the Prostate to expand are still poorly known. In general, dihydrotestosterone (DHT), a metabolite of
testosterone, is traditionally believed to be a critical mediator of prostatic growth (Rhodes et al., 1993). DHT is derived from
testosterone in certain tissues such as the prostate gland via the activity of 5α-reductase.
Medication for the Treatment of mild to moderate BPH has become a standard of care since well-designed clinical studies showed
that finasteride, a 5α-reductase inhibitor (5-ARI), and terazosin, an α-blocker, considerably improved LUTS and improved peak urinary flow rates in men with BPH drug-related adverse Effects related to α-blockers (e.g., postural hypotension and retrograde ejaculation) and also 5-ARIs (e.g.,
impairment of erectile dysfunction )phytotherapy including Native Americans were Known to utilize the fruit of saw palmetto to treat urinary and reproductive system problems (Suzuki et al., 2009). SPE is commonly Utilized to treat BPH in Europe
Disparity in composition Of SPE may contribute to heterogeneity in efficiency (Habib and Wyllie, 2004). Different products derived
from precisely the exact same plant can have distinct activity as a result of differences in the makeup of bioactive components in
the plant extracts (Novara et al., 2016). Many SPE goods were found to possess significantly different comparative contents of
putative active elements, fatty acids and phytosterols
Permixon included the Highest content (>80 percent ) of fatty acids among 14 products available in Europe (Habib and Wyllie, 2004
). Permixon also revealed the maximum efficiency in inhibition of 5α-reductase (Scaglione et al., 2012). Consistently, clinical
studies with Permixon have produced reproducible results of development of urinary symptoms
These data suggested that Various manufacturers of SPE may show marked variation in articles. Therefore, standardization of SPE
formulation, and control of the content of active elements in SPE may be critical to attaining consistent efficacy of SPE and
recommendations for its use in prevention and therapy of BPH
Lipidosterolic extract of saw palmetto, is the most studied type of SPE and studies with Permixon have produced relatively
consistent beneficial effects on LUTS at preclinical and clinical levels.
Saw Palmetto pills for hair loss
A systematic overview of Saw Palmetto examined for alopecia contained a study in which 38 percent of patients at the Saw Palmetto
cohort had an increase in hair growth, mainly on the vertex. This was compared to Finasteride, compared to that Saw Palmetto had a
poor percent, but it had been useful nonetheless.
Besides systemic Therapy, SP has also been analyzed as a topical agent. A study evaluating the hair growth effect of 3.3 mL
topical SP serum employed for 4 months and 2 mL cream for 24 weeks, in 50 men with AGA, revealed increased terminal and average
hair counts at 12 and 24 weeks . Although systemic SP hasn’t shown superiority to conventional systemic therapies, it does
have clinical benefits and is an attractive alternative remedy for male AGA patients that are not interested in oral finasteride.
Side effects of saw palmetto pills
Generally, saw palmetto extracts are well tolerated in men with BPH. There is agreement that negative effects of saw palmetto
extracts are mild and few, which their incidences Aren’t considerably different compared to placebo
The Most Often reported adverse events are More serious adverse events like death and cerebral hemorrhage are reported in isolated
case reports and data from spontaneous reporting strategies, but causality is questionable. No drug interactions were reported.
Presently available data suggest that S. repens is well tolerated by most users and isn’t associated with severe adverse events.
The majority of adverse events are mild, reversible and infrequent, and include abdominal pain, diarrhea, nausea and tiredness,
headache, decreased libido and rhinitis. We found no evidence for drug interactions with S. repens.
Saw Palmetto pills advantages
The exact mechanisms of Action of SPE are unfamiliar in alleviating LUTS associated with BPH.
The bioactive components Of SPE are considered to be fatty acids and phytosterols (Table 1
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859144/table/Tab1/]). The makeup of the various brands of saw palmetto varies
depending on extraction methods, source of the plant, and additional ingredients (Penugonda and Lindshield, 2013). The content of
total free fatty acids has been found to vary from 40.7 to 80.7percent (Table 1
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859144/table/Tab1/]) from 14 SPE extracts commercially available for the treatment
Fatty acids are the important Components of SPE. The primary fatty acids at SPE revealed α1-adrenergic receptor-binding activity
and inhibitory effects on 5α-reductase (Abe et al., 2009a; 2009b), indicating that fatty acids at SPE contribute to relieving BPH
symptoms through relaxation of muscle tone and inhibition of testosterone metabolism.
Phytosterols are relatively Minor constituents (Table 1 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859144/table/Tab1/]) of SPE
(Penugonda and Lindshield, 2013; Weisser et al., 1996). Studies have indicated that phytosterols can be beneficial in BPH therapy
Because of Their anti-inflammatory and anti-microbial effects
In Summary, saw Palmetto extract has curative potential. However, efficacy of SPE has been proven to be inconsistent, at least
partly because of lack of standardization of the SPE formula. Free fatty acids such as lauric acid, the main components of SPE,
have been demonstrated to be effective in inhibition of 5α-reductase and phytosterol (β-sitosterol), small constituents of SPE,
has been found to effectively reduce prostatic inflammation. Multiple instead of single mechanisms may be involved in the
beneficial effects of SPE in BPH therapy. Therefore, it’s important to standardize SPE goods for continual efficacy and also to
allow recommendations for SPE use in prevention and treatment of BPH.
One study even Demonstrated that Saw Palmetto may be able to be utilized to prevent or cure erectile dysfunction. However, this is
a rat research, therefore human information in this respect remains incomplete.
Saw Palmetto for Breast Enlargement
This has been promoted in some circles because of the Presence of phytoestrogens in Saw Palmetto. However, the literature has not
supported this claim to date.
As Soon as You parse out the literature, it appears that the Only type of Saw Palmetto which has shown any effect has specifically
Been the liquid extract form. In Europe, this is the Promixon merchandise. And now In the Unites States, the sole Saw Palmetto
product accepted by the USP is Flowmentum. Thus, make sure to look for the liquid extract form of Saw Palmetto, instead of the
numerous powder infusion products out on the market. Along with its low side effect profile, the liquid extract form of Saw
Palmetto should Make for a rewarding attempt when combatting the urinary symptoms of BPH. Heck, it Shows benefit for baldness
also, but this is part of another one discussion.